4Monkeys escape the Alpha Genesis lab in Yemassee, South Carolina

Police are warning residents in rural South Carolina to close their doors and windows after at least 43 monkeys escaped from a bio-research lab.

The rhesus macaques slipped out of an Alpha Genesis facility in Yemassee — which is just off I-95 in the southern part of the state — Wednesday night.

The company provides “primate research and development support to the scientific community,” according to its website.

None of the escaped primates were recaptured on Thursday morning.

“We want to reassure the community that there is no health risk associated with these animals,” the Yemassee Police Department said.

Police and Alpha Genesis staff have “strategically” set up traps around the area and are using thermal cameras to track the monkeys.

Local residents have been warned “to keep doors and windows secured to prevent these animals from entering their homes,” according to police.

Residents are told not to approach the loose monkeys and instead call 911 and report the sighting.

The Beaufort County Sheriff’s Office and state agriculture and wildlife officials are working with local officers “to deal with this incident efficiently and humanely,” Yemassee police said.

It is unclear how the primates managed to break out.

Alpha Genesis Inc. did not immediately respond to The Post’s request for comment.

Rhesus macaques originally come from India and China and are known for their high intelligence, according to National Geographic.

Apes have a long history in human medical and scientific research—and even preceded humans in space.

Yemassee is a small town of about 1,000 people in Beaufort and Hampton counties in South Carolina’s Lowcountry, about 80 miles northwest of Savannah, Ga.