San Francisco 49ers vs Miami Dolphins picks, odds for NFL week 16 game

On December 20, 2024By Littum

The San Francisco 49ers and Miami Dolphins play Sunday, Dec. 22 at Miami’s Hard Rock Stadium in a game on the NFL Week 16 schedule.

Which team will win the NFL Week 16 game?

Check out these NFL Week 16 picks and NFL Week 16 predictions for the game, which can be seen at 2:25 PM MST on CBS (stream with FUBO).

The Dolphins are a 1.5-point favorite over the 49ers in NFL Week 16 odds for the game, courtesy of BetMGM Sportsbook.

Miami is -125 on the moneyline, while San Francisco is +105.

Over/under (point total) is set to 46 points.

Watch 49ers at Dolphins with FUBO (Free Trial)

Jeremy Cluff writes: “Both of these teams had high expectations this season and have failed to live up to those expectations. The 49ers, however, are just a mess.”

Bookies.com: Play over in the 49ers vs Dolphins game

Bill Speros writes: “49ers are the latest victim of the NFL’s relentless ‘We Lost The Super Bowl Hangover.’ San Francisco is likely out of the postseason. The Dolphins hit in their 20-12 loss at Houston. Miami needs a win here home still alive in the NFC West, but we’re not sure even Robert Oppenheimer could figure out the math that finally 5 games at home have gone into the total points.”

The site’s formula predicts the 49ers will win the NFL Week 16 game against the Dolphins.

ESPN: The 49ers have a 55% chance to beat the Dolphins on Sunday

The site gives the Dolphins a 44.6% chance to win the NFL Week 16 game, with the remaining percentage standing for a tie.

Dimers: Dolphins 24, 49ers 24

That’s right. The site predicts a draw in this match on Sunday. It writes: “After extensive simulations, our model gives the 49ers a 52% win probability, while the Dolphins have a 48% win probability.”

Sportsman: Dolphins 24, 49ers 21

Matt Johnson writes: “Both teams are beat up heading into Week 16, with uncertainty at both tackle spots on the Miami Dolphins’ offensive line while the San Francisco 49ers deal with absences on both sides of the ball. Miami’s run defense – 83.3 rush ypg in last eight games – still holding up well, which could be enough in a low-scoring game.”

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Well Jeremy Cluff at [email protected]. Follow him on X, formerly Twitter @Jeremy_Cluff.

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